My website and this blog provide what I hope is an useful educational resource for my patients and others, but I know that many patients with snoring and obstructive sleep apnea will never reach it.  As such, I have contributed to two online resources that reach larger audiences.  I am a content author for sleep surgery at About.com, writing the pages for the Pillar Procedure, palate surgery, tongue region (aka hypopharyngeal) surgery, and jaw advancement surgery (maxillomandibular advancement).  In addition, the American Academy of Sleep Medicine recently updated their pages at SleepEducation.com related to surgical treatment of snoring and obstructive sleep apnea.  The edits I provided on the Surgery Overview and Procedures pages were an attempt to indicate that surgery, although far from perfect, is a treatment option and that a wide variety of surgical options have been developed over the past 10-20 years.

CPAP treatment of sleep apnea may lead to weight gain, not weight loss

The October 2013 issue of the Journal of Clinical Sleep Medicine included a study and editorial relating to a common problem faced by patients with obstructive sleep apnea who may be overweight.  Weight gain is a major risk factor for sleep apnea, and so too does sleep apnea contribute to weight gain.  Many patients with sleep apnea find that they experience fatigue or sleepiness, making it extremely difficult for them to exercise and burn calories.  In addition, obstructive sleep apnea may affect various hormones, such as leptin and ghrelin, that are involved in food intake.  The detailed explanation is more complicated, but on a basic level the increase in calorie intake and decrease in calorie burning can make weight loss challenging.  It has commonly been felt that treatment of sleep apnea, for example with positive airway pressure therapy, will restore energy levels and normalize hormone levels, enabling weight loss to occur.

The study published in the journal comes from the APPLES study, a randomized trial of 6 months of positive airway pressure (CPAP) therapy to treat obstructive sleep apnea.  What this study showed was that those patients who received sham (fake) positive airway pressure had no change in their weight.  In contrast, those who received real CPAP actually had a weight gain.  The amount of weight gain, on average, was low (0.35 kg), but the striking finding was that the more the patients used CPAP, the more weigh they gained–for every increase of 1 hour in usage per night, the additional weight gain was 0.42 kg.  It turns out that other studies (although not all studies) have shown similar findings, but the strength of this study was that it was a large, randomized trial and that it demonstrated such a strong relationship between more CPAP use and more weight gain.  Although this has never been studied for surgery, but my experience is that surgery does not have the same weight gain.  Some patients, for reasons that are not clear, will lose weight right after surgery due to pain in their throat and then can have additional weight loss over time.  I wonder if there is some sort of cycle between sleep apnea and weight gain that is broken, enabling them to lose weight.  Clearly, we need to learn more about the relationship between sleep apnea and body weight.

Patients need accurate information about treatments for snoring and obstructive sleep apnea.  In many cases, relying on our own knowledge base and expectations are sufficient, but everyone–patients and physicians alike–should seek out information and conduct studies to check these expectations against reality.  Challenging accepted wisdom is the reason that I perform research, and I encourage patients and colleagues (surgeons and non-surgeons) to do the same with me.

4 Responses to “Providing Accurate Information to Patients: About.com, SleepEducation.com, and Weight Gain Associated with CPAP”

  1. Steven Wu

    Yes! Eric, I can’t agree with you more. I think sleep surgery could be the start and key stone to break the vicious cycle of OSA and overweight. People always appreciate me their weight loss after OSA surgery.

    Reply
  2. Max Kenny

    Hi, I have always been on the stocky side but try and keep as trim as possible with my diet and kept at 78kg ( 5’7” male) , walking the dog daily was my regular exercise but when she passed I did less walking but kept the weight the same. I was eventually diagnosed with Sleep Apnea with 68 episodes an hour and put straight on Cpap. It took a few months to get used to but now I’m averaging 6 per hour . I am now able to walki3 miles a day without any problems, I’m on meds for PAF but dispite the extra exercise I have put on 5kg and gone from a 34 waist to a 36 in 6 months I told the sleep clinic but they said tell my doctor.

    Reply
  3. Shannon

    Max,

    I put on 15 lbs in the first month, 9 of them in the first 9 days, and I did nothing different. I know two more people who have suffered the same, and a lady (now deceased), who went on the CPAP machine, wasn’t eating, and lost no weight at all. I don’t know any more about the deceased lady’s history, but we three, completely independently of each other, because we had no idea the others were even on CPAP machines let alone suffering consequences, had test after test after test to see what was wrong with us, and it turns out that all three of us are healthy–but we’ve packed on this weight very fast.

    The connection seems to be the new machines with the card readers, the electronic ones. One of the people I know had been on a CPAP machine for 15 years (a new one every 5 years) without a problem, switched to the new kind that can monitor your sleep episodes, and put on 15 lbs in a very short time. When I found out, I told him about my experience, he returned his machine and went back to his older model and has lost most of the weight again, without having done anything different.

    The problem is real, with a tangible cause. Just because the experts haven’t put two and two together doesn’t mean it doesn’t exist (my CPAP consultant actually scoffed at me). They just haven’t realised it yet or figured out the science behind it.

    Reply
    • Dr. Kezirian

      This is very interesting and is not something I have ever heard before. I would not expect the newer CPAP machines that send usage information through cellular technology would specifically cause someone to gain weight, so I can certainly understand why someone would have doubted it. It turns out that studies with the older units (whether with cards or without any tracking of usage) showed that, on average, patients were gaining weight when placed on CPAP too. What is most interesting about what you have shared is that someone lost weight after going back to their older model. All I can say is that most of my patients do not gain weight quickly like this when starting with CPAP.

      Reply

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