As the surgical treatment of snoring and obstructive sleep apnea are relatively new fields, Dr. Kezirian uses the latest research advances to improve the care of his patients and to teach patients as well other physicians about new developments.

Dr. Kezirian is actively engaged in a wide variety of research efforts, and he is recognized nationally and internationally for this work. His research has been sponsored by the National Institutes of Health (NIH), the American Academy of Otolaryngology—Head and Neck Surgery Foundation, and the American Laryngological, Rhinological, and Otological Society (aka Triological Society). Based on his expertise, Dr. Kezirian works with several established and startup health care companies (and has his own patents) in work developing new treatments for snoring and obstructive sleep apnea. Although the research involved in these projects is confidential in the early stages, Dr. Kezirian is committed to making these available as soon as they have demonstrated clear benefits.

A full list of Dr. Kezirian’s research publications is available on his curriculum vitae or the National Library of Medicine website. Using the National Library of Medicine link, you will find some of these publications available free of charge. They are noted as “Free PMC Article” or “Free Article”. Dr. Kezirian often discusses his previous research in more detail on his blog. Here are some highlights of some of Dr. Kezirian’s snoring and sleep apnea surgery research.

Drug-Induced Sleep Endoscopy

There are many snoring and sleep apnea procedures available to treat patients. These procedure address the different structures of the nose and throat that can play important roles in causing snoring and obstructive sleep apnea. Successful surgical treatment is based on accurately identifying where the snoring and blockage in breathing is occurring and developing targeted, effective treatment. Dr. Kezirian jokes that he could come to each patients’ home and look inside their throat with a flexible fiberoptic telescope to watch the areas where blockage in breathing occurs as they sleep, all night, every night. Of course, this would be a little challenging, so we have to look for other options.

Drug-induced sleep endoscopy was developed in Europe as an evaluation for patients with snoring and sleep apnea who are considering surgery. During the procedure, surgeons look inside the throat with a flexible fiberoptic endoscope while a patient is sedated in the operating room. Dr. Kezirian is one of the world’s leaders in evaluation techniques that are essential to selecting surgical procedures, including drug-induced sleep endoscopy. His research has evaluated important characteristics of drug-induced sleep endoscopy, compared it to other evaluations, and examined surgical results. For additional information about this ongoing research, please see the National Institutes of Health’s website and USC’s clinical trials website.

Dr. Kezirian’s research on drug-induced sleep endoscopy has evolved from focusing on his own experience to leading major research collaborations through the International Surgical Sleep Society. This research has used a more-rigorous approach to show exactly how drug-induced sleep endoscopy can improve sleep apnea surgery results and how drug-induced sleep endoscopy findings are associated with results of Inspire Upper Airway Stimulation.  A second study of drug-induced sleep endoscopy and Upper Airway Stimulation outcomes is underway.  They are the largest studies in this area. The studies have been supported by the American Academy of Otolaryngology—Head and Neck Surgery Foundation and the American Sleep Medicine Foundation, the foundation arm of the American Academy of Sleep Medicine and was the first original surgical research study ever funded by this organization.

Magnetic Resonance Imaging and Sleep Apnea Surgery

Magnetic resonance imaging (MRI) allows physicians to learn more about anatomy without exposure to the radiation that comes with many radiology evaluations (like cone-beam computed tomography, or CBCT). MRI has been used for many years in research centers for the study of obstructive sleep apnea, and a fascinating study using MRI was published explaining the importance of obesity in sleep apnea and their complex relationship.

The USC Viterbi School of Engineering at the University of Southern California is one of top engineering schools in the world, and the faculty include some experts in sleep apnea research. Sleep Health Using Bioengineering (SleepHuB) is a research collaboration formed to deepen the combined efforts of medical and engineering colleagues with an interest in snoring and sleep apnea. Dr. Kezirian has partnered with leading MRI researchers at USC (Krishna Nayak, PhD) and the University of Pennsylvania (Richard Schwab, MD) in research using head and neck MRI in sleep apnea surgery patients. The goal of the research is to improve the selection of sleep apnea surgery procedures to achieve successful results.

Dr. Kezirian is also working with experts in magnetic resonance imaging at the USC Laboratory of NeuroImaging like Arthur Toga, PhD to examine the changes that occur in the brain with sleep apnea and the potential reversal of those changes with sleep apnea treatment.

For additional information, please see the description at the National Institutes of Health’s website and USC’s clinical trials website.

Examining Results for Inspire Medical’s Upper Airway Stimulation

Inspire Medical’s Upper Airway Stimulation system remains one of the most exciting recent breakthroughs in the treatment of obstructive sleep apnea. Dr. Kezirian and Keck Medicine of USC were the first center in the western United States to offer this therapy. Our continued enthusiasm for Upper Airway Stimulation as an important sleep apnea treatment is based on the excellent results we have seen in our patients. We believe that our results reflect the combination of:

• the Upper Airway Stimulation technology and the support of Inspire Medical personnel

• careful selection of appropriate patients, relying heavily on drug-induced sleep endoscopy

• shared commitment to patient care from the entire surgical and sleep medicine teams

With this foundation to deliver the best results for patients, we are one of just a few centers in the country that are part of two studies supported by Inspire Medical. The first study is what is called a post-FDA approval study. Inspire Medical was asked to conduct this study as part of the approval for sale in the United States. The purpose is to evaluate the results in patients receiving the treatment after approval, just to confirm that the excellent results of their STAR Trial remain consistent in another group of patients.

The second study is a registry study that looks at all patients who have received the device, without the same number of sleep studies and other evaluations that are part of the post-FDA approval study.

Dr. Kezirian has substantial experience with the approach of hypoglossal nerve stimulation. He was a key researcher in the work of a company called Apnex Medical, examining their results at 6 months and then 12 months after surgical implantation of their device. These studies were important in showing the value of hypoglossal nerve stimulation in the treatment of obstructive sleep apnea, including its role in treating blockage in breathing in both the Tongue Region and the Palate Region.

Sleep Apnea Surgery Practice Patterns and Procedure Selection

A first study examined national obstructive sleep apnea surgical treatment patterns using large databases developed by the Agency for Healthcare Research and Quality. This work characterized the number, types, and costs of surgeries performed in the United States. An estimated 35,000 procedures were performed nationally to treat obstructive sleep apnea in 2006, but only 20% included procedures to treat blockage in breathing in the tongue region. Research studies, including Dr. Kezirian’s own work, suggest that blockage in the tongue region occurs much more often than in just 20% of cases.

Dr. Kezirian is now working with a team of colleagues from the American Academy of Otolaryngology—Head and Neck Surgery on another study examining these issues in more detail using data from several large health care organizations, although not on a national level.

To explore the factors involved in procedure selection, Dr. Kezirian completed another study, finding that insufficient training in these techniques is a major barrier to performing tongue region procedures for many surgeons. As many of these procedures are relatively new, technically more difficult, and associated with a higher risk of complications, Dr. Kezirian is committed to the training of surgeons across the country and around the world in the techniques and the avoidance of complications.

The findings of this research are presented in more detail on a posting on Dr. Kezirian’s blog.

Measuring the Effectiveness of Sleep Apnea Surgery

Obstructive sleep apnea is treated because it has important adverse effects on health and daytime function (sleepiness, quality of life, and alertness). Surgical outcomes are measured by comparing the preoperative and postoperative sleep studies to determine the improvement in breathing patterns. While this is essential, this research considered the potential benefits on health and daytime function with a combination of blood tests and questionnaires. This published study showed that patients who achieve resolution of significant sleep apnea also have marked improvement in health and daytime function, but some patients whose sleep apnea did not resolve can also improve in daytime function. For additional information, please see the description at the National Institutes of Health website.

Obstructive Sleep Apnea in Older Adults

Most of the research describing the impact of obstructive sleep apnea has focused on young and middle-aged adults. Two large, national studies have allowed researchers to examine the impacts in older women and men. Dr. Kezirian has worked with the lead investigators from these studies to examine the quality of life and health consequences of obstructive sleep apnea in older adults. Researchers have wondered for many years whether sleep symptoms like sleepiness or decreased quality of life due to sleep issues were related to sleep apnea or the fact that adults over 60 years of age generally get less sleep than young and middle-aged adults. Dr. Kezirian’s research was the first to show that these symptoms are more closely related to sleep time rather than sleep apnea. In fact, this work has led to changes in the way that older adults with mild to moderate sleep apnea are treated.

Another research study evaluated one of many possible reasons why snoring and sleep apnea are more common in people as they age. This study suggested that collagen and elastin decrease over time in the hyoepiglottic ligament. These changes are similar to those that occur in the skin, providing one reason to explain the greater likelihood of airway airway related to the epiglottis in older patients that Dr. Kezirian sees in drug-induced sleep endoscopy. These patients with epiglottis-related obstruction are often candidates for hyoid suspension or epiglottis surgery.